The Valuable Role of ARMC1 in Invasive Breast Cancer as a Novel Biomarker.

ABSTRACT:

Background

Invasive breast carcinoma (BRCA) is a common type of breast cancer with a high clinical incidence. Thus, it is significant to find effective biomarkers for BRCA diagnosis and treatment. Although some members of armadillo (ARM) repeat family of proteins are confirmed to be biomarkers in cancers, the role of armadillo repeat-containing 1 (ARMC1) in BRCA remains unknown.

Methods

We firstly analyzed the ARMC1 expression in normal breast tissues and BRCA samples and its association with overall survival by the public database. Next, the χ ² test was used to evaluate the prognostic significance of ARMC1 expression in TCGA-BRCA patient samples. The ARMC1 mutations in BRCA were explored in the cBioportal database. Besides, the Gene Ontology (GO) and Kyot

SUBMITTER: Gan Y 

PROVIDER: S-EPMC8976651 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature