¹H MR spectroscopy biomarkers of neuronal and synaptic function are associated with tau deposition in cognitively unimpaired older adults.

ABSTRACT: Proton magnetic resonance spectroscopy (¹H MRS) may provide information on pathophysiological changes associated with tau deposition in cognitively unimpaired older adults. In this study, the associations of posterior cingulate gyrus tau and amyloid beta (Aβ) deposition on PET with ¹H MRS metabolite ratios acquired from bilateral posterior cingulate gyri were investigated in cognitively unimpaired older adults. Participants (n = 40) from the Mayo Clinic Study of Aging underwent single-voxel sLASER ¹H MRS from the posterior cingulate gyrus at 3 Tesla, ¹⁸F-flortaucipir, and ¹¹C- Pittsburgh Compound B (PiB) PET. An increase in posterior cingulate gyrus tau deposition, but not elevated Aβ, was associated with lower N-acetylaspartate/total

SUBMITTER: Kara F 

PROVIDER: S-EPMC8976711 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature