The Extracellular ATP Receptor P2RX7 Imprints a Promemory Transcriptional Signature in Effector CD8⁺ T Cells.

ABSTRACT: Development of CD8⁺ central memory T (Tcm) and resident memory T (Trm) cells, which promote immunity in the circulation and in barrier tissues, respectively, is not completely understood. Tcm and Trm cells may arise from common precursors; however, their fate-inducing signals are elusive. We found that virus-specific effector CD8⁺ T cells display heterogeneous expression of the extracellular ATP sensor P2RX7. P2RX7-high expression is confined, at peak effector phase, to CD62L⁺ memory precursors, which preferentially form Tcm cells. Among early effector CD8⁺ T cells, asymmetrical P2RX7 distribution correlated with distinct transcriptional signatures, with P2RX7-high cells enriched for memory and tissue residency sets. P2RX7-high early effectors pr

SUBMITTER: Vardam-Kaur T 

PROVIDER: S-EPMC8976739 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature