An Epidemic Zika Virus Isolate Drives Enhanced T Follicular Helper Cell and B Cell-Mediated Immunity.

ABSTRACT: Zika virus (ZIKV) is a mosquito-borne pathogen that recently caused a series of increasingly severe outbreaks. We previously demonstrated that, compared with a pre-epidemic isolate (ZIKV^CDN), a Brazilian ZIKV isolate (ZIKV^BR) possesses a novel capacity to suppress host immunity, resulting in delayed viral clearance. However, whether ZIKV^BR modulates CD4 T cell responses remains unknown. In this study, we show that, in comparison with ZIKV^CDN infection, CD4 T cells are less polarized to the Th1 subtype following ZIKV^BR challenge in mice. In contrast, we observed an enhanced accumulation of T follicular helper cells 10, 14, and 21 d postinfection with ZIKV^BR This response correlated with an enhanced germinal center B cell resp

SUBMITTER: Pardy RD 

PROVIDER: S-EPMC8976755 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature