Influence of Self-MHC Class I Recognition on the Dynamics of NK Cell Responses to Cytomegalovirus Infection.

ABSTRACT: Although interactions between inhibitory Ly49 receptors and their self-MHC class I ligands in C57BL/6 mice are known to limit NK cell proliferation during mouse CMV (MCMV) infection, we created a 36-marker mass cytometry (CyTOF) panel to investigate how these inhibitory receptors impact the NK cell response to MCMV in other phenotypically measurable ways. More than two thirds of licensed NK cells (i.e., those expressing Ly49C, Ly49I, or both) in uninfected mice had already differentiated into NK cells with phenotypes indicative of Ag encounter (KLRG1⁺Ly6C^-) or memory-like status (KLRG1⁺Ly6C⁺). These pre-existing KLRG1⁺Ly6C⁺ NK cells resembled known Ag-specific memory NK cell populations in being less responsive to IL-18 and

SUBMITTER: Potempa M 

PROVIDER: S-EPMC8976824 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature