Exposure to air pollution and risk of incident dementia in the UK Biobank.

ABSTRACT:

Background

Air pollution may cause inflammatory and oxidative stress damage to the brain, leading to neurodegenerative disease. The association between air pollution and dementia, and modification by apolipoprotein E genotype 4 (APOE-ε4) has yet to be fully investigated.

Objectives

To examine associations of air pollution with three types of incident dementias (Alzheimer's disease (AD), frontotemporal dementia (FTD), and vascular dementia (VAD)), and their potential modification by APOE-ε4 genotype.

Methods

The UK Biobank enrolled >500,000 participants (2006-2010) with ongoing follow-up. We used annual averages of air pollution (PM_2.5, PM₁₀, PM_2.5-10, PM_{2.5absorbance}, NO₂, NO_X) for 2010 scaled to interq

SUBMITTER: Parra KL 

PROVIDER: S-EPMC8976829 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature