Mathematical modelling identifies conditions for maintaining and escaping feedback control in the intestinal epithelium.

ABSTRACT: The intestinal epithelium is one of the fastest renewing tissues in mammals. It shows a hierarchical organisation, where intestinal stem cells at the base of crypts give rise to rapidly dividing transit amplifying cells that in turn renew the pool of short-lived differentiated cells. Upon injury and stem-cell loss, cells can also de-differentiate. Tissue homeostasis requires a tightly regulated balance of differentiation and stem cell proliferation, and failure can lead to tissue extinction or to unbounded growth and cancerous lesions. Here, we present a two-compartment mathematical model of intestinal epithelium population dynamics that includes a known feedback inhibition of stem cell differentiation by differentiated cells. The model shows that feedback regulation stabilises the number

SUBMITTER: Fischer MM 

PROVIDER: S-EPMC8976856 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature