Digoxin Impact on Heart Failure Patients with Atrial Fibrillation.

ABSTRACT:

Background

Digoxin is a cardiac glycoside, derived from the plant Digitalis purpurea. For many years digitalis has been widely used in the treatment of heart failure (HF), owing to its cardiotonic and neurohormonal effects and atrial fibrillation (AF), due to its parasympathomimetic effect on the AV node.

Objective

The aim of this paper is to evaluate the available evidence on the safety and efficacy of digoxin in patients with HF and AF, by reviewing the pertinent literature.

Methods

We conducted a PubMed/MEDLINE and SCOPUS search to evaluate the currently available evidence on the administration of digoxin and its association with all-cause mortality risk in patients with AF and HF.

Results

Several observational analyses of clinical trials and meta-analyses h

SUBMITTER: Gerakaris A 

PROVIDER: S-EPMC8976896 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature