Anterior cingulate neurons signal neutral cue pairings during sensory preconditioning.

ABSTRACT: Of all frontocortical subregions, the anterior cingulate cortex (ACC) has perhaps the most overlapping theories of function.^1-3 Recording studies in rats, humans, and other primates have reported diverse neural responses that support many theories,^4-12 yet nearly all these studies have in common tasks in which one event reliably predicts another. This leaves open the possibility that ACC represents associative pairing of events, independent of their overt biological significance. Sensory preconditioning¹³ provides an opportunity to test this. In the first phase, preconditioning, value-neutral sensory stimuli are paired (A→B). To test whether this was learned, subjects are given standard conditioning during which one of the previously neutral sensory cues is

SUBMITTER: Hart EE 

PROVIDER: S-EPMC8976914 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature