High-affinity, neutralizing antibodies to SARS-CoV-2 can be made without T follicular helper cells.

ABSTRACT: T follicular helper (T_FH) cells are the conventional drivers of protective, germinal center (GC)–based antiviral antibody responses. However, loss of T_FH cells and GCs has been observed in patients with severe COVID-19. As T cell–B cell interactions and immunoglobulin class switching still occur in these patients, noncanonical pathways of antibody production may be operative during SARS-CoV-2 infection. We found that both T_FH-dependent and -independent antibodies were induced against SARS-CoV-2 infection, SARS-CoV-2 vaccination, and influenza A virus infection. Although T_FH-independent antibodies to SARS-CoV-2 had evidence of reduced somatic hypermutation, they were still high affinity, durable, and reactive against diverse spike-derived epitopes

SUBMITTER: Chen JS 

PROVIDER: S-EPMC8977051 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature