Psychosocial stress increases risk for type 2 diabetes in female cynomolgus macaques consuming a western diet.

ABSTRACT: Chronic psychosocial stress is associated with increased risk of many chronic diseases including type 2 diabetes mellitus. However, it is difficult to establish a causal relationship between stress and diabetes in human studies because stressors often are self-reported and may be distant in time from metabolic consequences. Macaques are useful models of the effects of chronic psychosocial stress on health and may develop obesity and diabetes similar to human beings. Thus, we studied the relationships between social subordination stress - a well-validated psychological stressor in macaques - and body composition and carbohydrate metabolism in socially housed, middle-aged female cynomolgus monkeys (Macaca fascicularis; n = 42). Following an 8-week baseline phase, the monkeys were fed a Weste

SUBMITTER: Silverstein-Metzler MG 

PROVIDER: S-EPMC8977247 | biostudies-literature | 2022 May

REPOSITORIES: biostudies-literature