QT prolongation in patients with index evaluation for seizure or epilepsy is predictive of all-cause mortality.

ABSTRACT:

Background

Refractory epilepsy confers a considerable lifetime risk of sudden unexplained death in epilepsy (SUDEP). Mechanisms may overlap with sudden cardiac death (SCD), particularly regarding QTc prolongation. Guidelines in the United States do not mandate the use of electrocardiography (ECG) in diagnostic evaluation of seizures or epilepsy.

Objective

The purpose of this study was to determine the frequency of ECG use and of QT prolongation, and whether QT prolongation predicts mortality in patients with seizures.

Methods

We performed a retrospective cohort study including all patients seen at Mayo Clinic in Rochester, Minnesota, from January 1, 2000, to July 31, 2015, with index evaluation for seizure or epilepsy. Patients with an ECG were categorized by the pres

SUBMITTER: Chahal CAA 

PROVIDER: S-EPMC8977248 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature