Decreased Susceptibility of <i>Shigella</i> Isolates to Azithromycin in Children in Tehran, Iran.

ABSTRACT: Azithromycin (AZT) has widely been used for the treatment of shigellosis in children. Recent studies showed a high rate of decreased susceptibility to azithromycin due to different mechanisms of resistance in Shigella isolates. Accordingly, the purpose of this study was to investigate the role of azithromycin resistance mechanisms of Shigella isolates in Iran during a two-year period. In this study, we investigated the mechanisms of resistance among Shigella spp. that were isolated from children with shigellosis. The minimum inhibitory concentration (MIC) of Shigella isolates to azithromycin was determined by the agar dilution method in the presence and absence of Phe-Arg-β-naphthylamide inhibitor. The presence of 12 macrolide resistance genes was investi

SUBMITTER: Behruznia P 

PROVIDER: S-EPMC8977332 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature