Neuroanatomical correlations of visuospatial processing in primary progressive aphasia.

ABSTRACT: Clinical phenotyping of primary progressive aphasia has largely focused on speech and language presentations, leaving other cognitive domains under-examined. This study investigated the diagnostic utility of visuospatial profiles and examined their neural basis among the three main primary progressive aphasia variants. We studied the neuropsychological performances of 118 primary progressive aphasia participants and 30 cognitively normal controls, across 11 measures of visuospatial cognition, and investigated their neural correlates via voxel-based morphometry analysis using visuospatial composite scores derived from principal component analysis. The principal component analysis identified three main factors: visuospatial-executive, visuospatial-memory and visuomotor components. Logopenic

SUBMITTER: Tee BL 

PROVIDER: S-EPMC8977647 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature