Dataset Information

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation.

ABSTRACT:

Purpose

We aimed to evaluate changes in dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) scans acquired before and after single-dose ablative neoadjuvant partial breast irradiation (NA-PBI), and explore the relation between semiquantitative MRI parameters and radiologic and pathologic responses.

Methods and materials

We analyzed 3.0T DCE and DW-MRI of 36 patients with low-risk breast cancer who were treated with single-dose NA-PBI, followed by breast-conserving surgery 6 or 8 months later. MRI was acquired before NA-PBI and 1 week, 2, 4, and 6 months after NA-PBI. Breast radiologists assessed the radiologic response and breast pathologists scored the pathologic response after surgery. Patients were grouped as either pathologic responders or nonresponders (<10% vs ≥10% residual tumor cells). The semiquantitative MRI parameters evaluated were time to enhancement (TTE), 1-minute relative enhancement (RE_1min), percentage of enhancing voxels (%EV), distribution of washout curve types, and apparent diffusion coefficient (ADC).

Results

In general, the enhancement increased 1 week after NA-PBI (baseline vs 1 week median - TTE: 15s vs 10s; RE_1min: 161% vs 197%; %EV: 47% vs 67%) and decreased from 2 months onward (6 months median - TTE: 25s; RE_1min: 86%; %EV: 12%). Median ADC increased from 0.83 × 10^-3 mm²/s at baseline to 1.28 × 10^-3 mm²/s at 6 months. TTE, RE_1min, and %EV showed the most potential to differentiate between radiologic responses, and TTE, RE_1min, and ADC between pathologic responses.

Conclusions

Semiquantitative analyses of DCE and DW-MRI showed changes in relative enhancement and ADC 1 week after NA-PBI, indicating acute inflammation, followed by changes indicating tumor regression from 2 to 6 months after radiation therapy. A relation between the MRI parameters and radiologic and pathologic responses could not be proven in this exploratory study.

SUBMITTER: Vasmel JE

PROVIDER: S-EPMC8977856 | biostudies-literature | 2022 Mar-Apr

REPOSITORIES: biostudies-literature

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Publications

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation.

Vasmel Jeanine E JE Groot Koerkamp Maureen L ML Mandija Stefano S Veldhuis Wouter B WB Moman Maaike R MR Froeling Martijn M van der Velden Bas H M BHM Charaghvandi Ramona K RK Vreuls Celien P H CPH van Diest Paul J PJ van Leeuwen A M Gijs AMG van Gorp Joost J Philippens Marielle E P MEP van Asselen Bram B Lagendijk Jan J W JJW Verkooijen Helena M HM van den Bongard H J G Desirée HJGD Houweling Antonetta C AC

Advances in radiation oncology 20211120 2

<h4>Purpose</h4>We aimed to evaluate changes in dynamic contrast-enhanced (DCE) and diffusion-weighted (DW) magnetic resonance imaging (MRI) scans acquired before and after single-dose ablative neoadjuvant partial breast irradiation (NA-PBI), and explore the relation between semiquantitative MRI parameters and radiologic and pathologic responses.<h4>Methods and materials</h4>We analyzed 3.0T DCE and DW-MRI of 36 patients with low-risk breast cancer who were treated with single-dose NA-PBI, follo ...[more]

PMID: 35387418

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Dataset Information

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation.

Purpose

Methods and materials

Results

Conclusions

Publications

Dynamic Contrast-enhanced and Diffusion-weighted Magnetic Resonance Imaging for Response Evaluation After Single-Dose Ablative Neoadjuvant Partial Breast Irradiation.

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