Cytoplasmic HDAC4 regulates the membrane repair mechanism in Duchenne muscular dystrophy.

ABSTRACT:

Background

Histone deacetylase 4 (HDAC4) is a stress-responsive factor that mediates multiple cellular responses. As a member of class IIa HDACs, HDAC4 shuttles between the nucleus and the cytoplasm; however, HDAC4 cytoplasmic functions have never been fully investigated. Duchenne muscular dystrophy (DMD) is a genetic, progressive, incurable disorder, characterized by muscle wasting, which can be treated with the unspecific inhibition of HDACs, despite this approach being only partially effective. More efficient strategies may be proposed for DMD only after the different HDAC members will be characterized.

Methods

To fully understand HDAC4 functions, we generated dystrophic mice carrying a skeletal muscle-specific deletion of HDAC4 (mdx;KO mice). The progression of muscular

SUBMITTER: Renzini A 

PROVIDER: S-EPMC8977968 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature