Interleukin-6 potentiates endurance training adaptation and improves functional capacity in old mice.

ABSTRACT:

Background

Interventions to preserve functional capacities at advanced age are becoming increasingly important. So far, exercise provides the only means to counteract age-related decrements in physical performance and muscle function. Unfortunately, the effectiveness of exercise interventions in elderly populations is hampered by reduced acceptance and compliance as well as disuse complications. We therefore studied whether application of interleukin-6 (IL-6), a pleiotropic myokine that is induced by skeletal muscle activity and exerts broad systemic effects in response to exercise, affects physical performance and muscle function alone or in combination with training in aged mice.

Methods

Sedentary old male mice (Sed+Saline, n = 15) were compared with animals that received

SUBMITTER: Leuchtmann AB 

PROVIDER: S-EPMC8978011 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature