High-sensitivity C-reactive protein levels and pregnancy outcomes in women with unexplained infertility after ovarian stimulation with intrauterine insemination in a multicenter trial.

ABSTRACT:

Objective

To determine if chronic inflammation, assessed by basal high-sensitivity C-reactive protein (hs-CRP) levels, is associated with pregnancy outcomes in women with unexplained infertility undergoing ovarian stimulation with intrauterine insemination.

Design

Prospective cohort analysis of the Reproductive Medicine Network's Assessment of Multiple Intrauterine Gestations from Ovarian Stimulation (AMIGOS) randomized controlled trial.

Setting

Multicenter university-based randomized controlled trial.

Patients

A total of 781 couples with unexplained infertility.

Interventions

Secondary analysis.

Main outcome measures

Adjusted risk ratios of live birth, clinical pregnancy, and pregnancy loss rates by hs-CRP levels.

Results

Associations betw

SUBMITTER: Gavrizi SZ 

PROVIDER: S-EPMC8978106 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature