Preconception hemoglobin A1c concentration in healthy women is not associated with fecundability or pregnancy loss.

ABSTRACT:

Objective

To examine the relationship of preconception hemoglobin A1c, a marker of cumulative exposure to glucose over the preceding 2-3 months, with time to pregnancy, pregnancy loss, and live birth among fecund women without diagnosed diabetes or other medical diseases.

Design

A secondary analysis of a prospective cohort of women participating in the Effects of Aspirin in Gestation and Reproduction (EAGeR) trial.

Setting

Four US academic medical centers.

Patients

A total of 1,194 healthy women aged 18-40 years with a history of one or two pregnancy losses attempting spontaneous conception were observed for up to six cycles while attempting pregnancy and throughout pregnancy if they conceived.

Interventions

Not applicable.

Main outcome measures

T

SUBMITTER: Zolton JR 

PROVIDER: S-EPMC8978107 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature