Imaging acute effects of bevacizumab on tumor vascular kinetics in a preclinical orthotopic model of U251 glioma.

ABSTRACT: The effect of a human vascular endothelial growth factor antibody on the vasculature of human tumor grown in rat brain was studied. Using dynamic contrast-enhanced magnetic resonance imaging, the effects of intravenous bevacizumab (Avastin; 10 mg/kg) were examined before and at postadministration times of 1, 2, 4, 8, 12 and 24 h (N = 26; 4-5 per time point) in a rat model of orthotopic, U251 glioblastoma (GBM). The commonly estimated vascular parameters for an MR contrast agent were: (i) plasma distribution volume (v_p ), (ii) forward volumetric transfer constant (K^trans ) and (iii) reverse transfer constant (k_ep ). In addition, extracellular distribution volume (V_D ) was estimated in the tumor (V_D-tumor ), tumor edge (V_D-edge

SUBMITTER: Nagaraja TN 

PROVIDER: S-EPMC8978145 | biostudies-literature | 2021 Jul

REPOSITORIES: biostudies-literature