Intraarterial Administration Boosts ¹⁷⁷Lu-HA-DOTATATE Accumulation in Salvage Meningioma Patients.

ABSTRACT: Intravenous ¹⁷⁷Lu-high-affinity (HA)-DOTATATE has shown promising results for the treatment of surgery- and radiotherapy-refractory meningiomas. We aimed to investigate the added value of intraarterial administration. Methods: Patients underwent at least 1 intravenous ¹⁷⁷Lu-HA-DOTATATE treatment first and subsequent intraarterial cycles. Inpatient and intrapatient comparison was based on posttreatment ¹⁷⁷Lu-HA-DOTATATE imaging 24 h after injection. The technical success rate and adverse events were recorded. Results: Four patients provided informed consent. The technical success rate was 100%, and no angiography-related or unexpected adverse events occurred. Intrapatient comparison showed an increased target lesion accumulation on both planar

SUBMITTER: Vonken EPA 

PROVIDER: S-EPMC8978193 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature