High affinity zoledronate-based metal complex nanocrystals to potentially treat osteolytic metastases.

ABSTRACT: Formation of several materials, denoted as bisphosphonate-based coordination complexes (BPCCs), resulted from the reaction between clinically employed bisphosphonate, zoledronate (ZOLE) and bioactive metals (M²⁺ = Ca²⁺, Mg²⁺ and Zn²⁺). Six ZOLE-based BPCCs were synthesized using different variables (M²⁺ : ZOLE molar ratio, temperature, pH, and anion) and their structures were elucidated by single crystal X-ray diffraction (ZOLE-Ca forms I and II, ZOLE-Mg forms I and II, and ZOLE-Zn forms I and II). The dissolution of the ZOLE-based BPCCs was compared to that of ZOLE (Reclast®). Most of the ZOLE-based BPCCs (60-85%, in 18-24 h) present a lower dissolution and equilibrium solubility than ZOLE (∼100%, 30 min) in phosphate buffered saline

SUBMITTER: Quinones Velez G 

PROVIDER: S-EPMC8978309 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature