Efficacy and safety of vedolizumab for pediatrics with inflammatory bowel disease: a systematic review.

ABSTRACT:

Background

Vedolizumab use in pediatrics is still off-label and the data are limited. We conducted a systematic review evaluating the efficacy and safety of vedolizumab in children and adolescents with inflammatory bowel disease (IBD).

Methods

PubMed, EMBASE and Cochrane databases were systematically searched for studies of vedolizumab in children and adolescents with IBD reporting clinical remission, response, corticosteroid-free (CS-free) remission, mucosal healing, or safety up to December 3^rd 2021.

Results

Ten studies, comprising 455 patients were included. For CD, the pooled clinical remission rates were 25% (19/75) at 6 weeks, 28% (25/85) at 14 weeks, 32% (17/53) at 22 weeks, and 46% (43/92) at 1 year. For UC/IBD-U, the pooled clinical remission rates

SUBMITTER: Fang S 

PROVIDER: S-EPMC8978350 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature