Effects of caloric restriction on the gut microbiome are linked with immune senescence.

ABSTRACT:

Background

Caloric restriction can delay the development of metabolic diseases ranging from insulin resistance to type 2 diabetes and is linked to both changes in the composition and metabolic function of the gut microbiota and immunological consequences. However, the interaction between dietary intake, the microbiome, and the immune system remains poorly described.

Results

We transplanted the gut microbiota from an obese female before (AdLib) and after (CalRes) an 8-week very-low-calorie diet (800 kcal/day) into germ-free mice. We used 16S rRNA sequencing to evaluate taxa with differential abundance between the AdLib- and CalRes-microbiota recipients and single-cell multidimensional mass cytometry to define immune signatures in murine colon, liver, and spleen. Recipients of

SUBMITTER: Sbierski-Kind J 

PROVIDER: S-EPMC8978410 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature