Magnetic resonance spectroscopic imaging of downfield proton resonances in the human brain at 3 T.

ABSTRACT:

Purpose

To develop an MRSI technique capable of mapping downfield proton resonances in the human brain.

Methods

A spectral-spatial excitation and frequency-selective refocusing scheme, in combination with 2D phase encoding, was developed for mapping of downfield resonances without any perturbation of the water magnetization. An alternative scheme using spectral-spatial refocusing was also investigated for simultaneous detection of both downfield and upfield resonances. The method was tested in 5 healthy human volunteers.

Results

Downfield metabolite maps with a nominal spatial resolution of 1.5 cm³ were recorded at 3 T in a scan time of 12 minutes. Cramer-Rao lower bounds for nine different downfield peaks were 20% or less over a single supraventricular sli

SUBMITTER: Povazan M 

PROVIDER: S-EPMC8978590 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature