Transgenerational Effects of Prenatal Ethanol Exposure in Prepubescent Mice.

ABSTRACT: Background: Fetal alcohol spectrum disorders (FASD) represent a leading cause of non-genetic neuropathologies. Recent preclinical evidence from suggests that prenatal ethanol exposure (PrEE), like other environmental exposures, may have a significant, transgenerational impact on the offspring of directly exposed animals, including altered neocortical development at birth and behavior in peri-pubescent mice. How these adverse behavioral outcomes are manifested within the brain at the time of behavioral disruption remains unknown. Methods: A transgenerational mouse model of FASD was used to generate up to a third filial generation of offspring to study. Using a multi-modal battery of behavioral assays, we assessed motor coordination/function, sensorimotor processing, risk-takin

SUBMITTER: Bottom RT 

PROVIDER: S-EPMC8978834 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature