Suicidal Ideation Is Associated With Reduced Functional Connectivity and White Matter Integrity in Drug-Naive Patients With Major Depression.

ABSTRACT: Depression is a highly prevalent psychiatric disorder affecting millions of people worldwide. Depression is characterized by decreased mood or loss of interest in daily activities, changes in feeding and circadian rhythms and significant impairments in cognitive and executive function. In addition, the occurrence of recurrent thoughts of death and suicidal ideation confers depressed patients a higher risk of suicide than the general population. With this study, we aimed to explore the neural correlates of suicidal ideation in drug-naïve patients diagnosed with depression. Twenty-five patients were scanned using two-different magnetic resonance imaging (MRI) modalities, resting state functional MRI (fMRI) and diffusion tensor imaging (DTI). Resting state allowed the exploration of connectiv

SUBMITTER: Reis JV 

PROVIDER: S-EPMC8978893 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature