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Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization.

ABSTRACT: A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the present synthetic method provides a straightforward strategy for the synthesis of quinazolin-4(3H)-ones.

SUBMITTER: Sun W

PROVIDER: S-EPMC8978923 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature

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Straightforward synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization.

Sun Wuji W Ma Xue X Pang Yuqi Y Zhao Lifeng L Zhong Qidi Q Liu Chunyan C Fan Qiangwen Q

RSC advances 20220107 3

A green, simple and efficient method is developed for the synthesis of quinazolin-4(3H)-ones via visible light-induced condensation cyclization of 2-aminobenzamides and aldehydes under visible light irradiation. The reaction proceeds using fluorescein as a photocatalyst in the presence of TBHP without the need for a metal catalyst. In addition, this reaction tolerates a broad scope of substrates and could afford a variety of desirable products in good to excellent yields. Thus, the ...[more]

PMID: 35425171

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