Invalidation of dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) as SARS-CoV-2 main protease inhibitors and the discovery of PGG as a papain-like protease inhibitor.

ABSTRACT: The COVID-19 pandemic spurred a broad interest in antiviral drug discovery. The SARS-CoV-2 main protease (M ^pro ) and papain-like protease (PL ^pro ) are attractive antiviral drug targets given their vital roles in viral replication and modulation of host immune response. Structurally disparate compounds were reported as M ^pro and PL ^pro inhibitors from either drug repurposing or rational design. Two polyphenols dieckol and 1,2,3,4,6-pentagalloylglucose (PGG) were recently reported as SARS-CoV-2 main protease (M ^pro ) inhibitors. With our continuous interest in studying the mechanism of inhibition and resistance of M ^pro inhibitors, we report herein our independent validation/invalidation of these two natural products. Our FR

SUBMITTER: Tan H 

PROVIDER: S-EPMC8978949 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature