Novel GxE effects and resilience: A case:control longitudinal study of psychosocial stress with war-affected youth.

ABSTRACT: Responses to early life adversity differ greatly across individuals. Elucidating which factors underlie this variation can help us better understand how to improve health trajectories. Here we used a case:control study of refugee and non-refugee youth, differentially exposed to war-related trauma, to investigate the effects of genetics and psychosocial environment on response to trauma. We investigated genetic variants in two genes (serotonin transporter, 5-HTT, and catechol-O-methyltransferase, COMT) that have been implicated in response to trauma. We collected buccal samples and survey data from 417 Syrian refugee and 306 Jordanian non-refugee youth who were enrolled in a randomized controlled trial to evaluate a mental health-focused intervention. Measures of lifetime trauma exposure, r

SUBMITTER: Mulligan CJ 

PROVIDER: S-EPMC8979449 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature