Spiers Memorial Lecture: Analysis and de novo design of membrane-interactive peptides.

ABSTRACT: Membrane-peptide interactions play critical roles in many cellular and organismic functions, including protection from infection, remodeling of membranes, signaling, and ion transport. Peptides interact with membranes in a variety of ways: some associate with membrane surfaces in either intrinsically disordered conformations or well-defined secondary structures. Peptides with sufficient hydrophobicity can also insert vertically as transmembrane monomers, and many associate further into membrane-spanning helical bundles. Indeed, some peptides progress through each of these stages in the process of forming oligomeric bundles. In each case, the structure of the peptide and the membrane represent a delicate balance between peptide-membrane and peptide-peptide interactions. We will review this

SUBMITTER: Kratochvil HT 

PROVIDER: S-EPMC8979563 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature