Germline variants disrupting microRNAs predict long-term genitourinary toxicity after prostate cancer radiation.

ABSTRACT:

Background and purpose

The purpose of this study was to determine whether single nucleotide polymorphisms disrupting microRNA targets (mirSNPs) can serve as predictive biomarkers for toxicity after radiotherapy for prostate cancer and whether these may be differentially predictive depending on radiation fractionation.

Materials and methods

We identified 201 men treated with two forms of definitive radiotherapy for prostate cancer at two institutions: 108 men received conventionally-fractionated radiotherapy (CF-RT) and 93 received stereotactic body radiotherapy (SBRT). Germline DNA was evaluated for the presence of functional mirSNPs. Random forest, boosted trees and elastic net models were developed to predict late grade ≥2 GU toxicity by the RTOG scale.

Results

The

SUBMITTER: Kishan AU 

PROVIDER: S-EPMC8979583 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature