Barcoded bulk QTL mapping reveals highly polygenic and epistatic architecture of complex traits in yeast.

ABSTRACT: Mapping the genetic basis of complex traits is critical to uncovering the biological mechanisms that underlie disease and other phenotypes. Genome-wide association studies (GWAS) in humans and quantitative trait locus (QTL) mapping in model organisms can now explain much of the observed heritability in many traits, allowing us to predict phenotype from genotype. However, constraints on power due to statistical confounders in large GWAS and smaller sample sizes in QTL studies still limit our ability to resolve numerous small-effect variants, map them to causal genes, identify pleiotropic effects across multiple traits, and infer non-additive interactions between loci (epistasis). Here, we introduce barcoded bulk quantitative trait locus (BB-QTL) mapping, which allows us to construct, genoty

SUBMITTER: Nguyen Ba AN 

PROVIDER: S-EPMC8979589 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature