Genomic and functional characterization of a mucosal symbiont involved in early-stage colorectal cancer.

ABSTRACT: Colorectal cancer is a major health concern worldwide. Growing evidence for the role of the gut microbiota in the initiation of CRC has sparked interest in approaches that target these microorganisms. However, little is known about the composition and role of the microbiota associated with precancerous polyps. Here, we found distinct microbial signatures between patients with and without polyps and between polyp subtypes using sequencing and culturing techniques. We found a correlation between Bacteroides fragilis recovered and the level of inflammatory cytokines in the mucosa adjacent to the polyp. Additional analysis revealed that B. fragilis from patients with polyps are bft-negative, activate NF-κB through Toll-like receptor 4, induce a pro-inflammatory response, and are enriched in ge

SUBMITTER: Kordahi MC 

PROVIDER: S-EPMC8979638 | biostudies-literature | 2021 Oct

REPOSITORIES: biostudies-literature