Efficacy of nano-hydroxyapatite on caries prevention-a systematic review and meta-analysis.

ABSTRACT:

Introduction/objectives

The review systematically explored in vivo or in situ studies investigating the efficacy of nano-hydroxyapatite (nHA) to reduce initiation of or to remineralize initial caries lesions.

Data

Prospective controlled (non-)randomized clinical trials investigating the efficacy of a nHA compared to any other (placebo) treatment or untreated/standard control.

Sources

Three electronic databases (Central Cochrane, PubMed-MEDLINE, Ovid EMBASE) were screened. Outcomes were, e.g., ICDAS score, laser fluorescence, enamel remineralization rate, mineral loss, and lesion depth. No language or time restrictions were applied. Risk of bias and level of evidence were graded using the Risk of Bias 2.0 tool and GRADE profiler.

Study selection/results

Five in

SUBMITTER: Wierichs RJ 

PROVIDER: S-EPMC8979882 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature