The role of oviduct-specific glycoprotein (OVGP1) in modulating biological functions of gametes and embryos.

ABSTRACT: Diverse lines of evidence indicate that the mammalian oviduct makes important contributions to the complex process of reproduction other than being simply a conduit for the transport of gametes and embryos. The cumulative synthesis and transport of proteins secreted by oviductal secretory cells into the oviductal lumen create a microenvironment supporting important reproductive events, including sperm capacitation, fertilization, and early embryo development. Among the components that have been identified in the oviductal fluid is a family of glycosylated proteins known collectively as oviduct-specific glycoprotein (OVGP1) or oviductin. OVGP1 has been identified in several mammalian species, including humans. The present review summarizes the work carried out, in various mammalian species,

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC8979936 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature