Genetic and environment effects on structural neuroimaging endophenotype for bipolar disorder: a novel molecular approach.

ABSTRACT: We investigated gene-environment effects on structural brain endophenotype in bipolar disorder (BD) using a novel method of combining polygenic risk scores with epigenetic signatures since traditional methods of examining the family history and trauma effects have significant limitations. The study enrolled 119 subjects, including 55 BD spectrum (BDS) subjects diagnosed with BD or major depressive disorder (MDD) with subthreshold BD symptoms and 64 non-BDS subjects comprising 32 MDD subjects without BD symptoms and 32 healthy subjects. The blood samples underwent genome-wide genotyping and methylation quantification. We derived polygenic risk score (PRS) and methylation profile score (MPS) as weighted summations of risk single nucleotide polymorphisms and methylation probes, respectively,

SUBMITTER: Hu B 

PROVIDER: S-EPMC8980067 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature