Production of insulin antibody associated with relapsed hodgkin's lymphoma.

ABSTRACT: A 72-year-old man with type 2 diabetes mellitus with good glucose control for 20 years and maintained on oral hypoglycaemic agents was diagnosed with Hodgkin's Lymphoma (HL) and started on insulin glargine for glycaemic control. Despite increased doses of insulin, his blood glucose levels went up dramatically. The anti-insulin antibody test proved to be positive, and Scatchard plot analysis showed 2 binding sites with relatively low-affinity constants: K ₁ = 0.0032, K ₂ = 0.0002 (10⁸/M); and high binding capacities: R ₁ = 98.4, R ₂ = 372 (10^-8 M), which were compatible with the features of antibody of insulin autoimmune syndrome (IAS). However, hypoglycaemia was not noted throughout the course of

SUBMITTER: Ikeda M 

PROVIDER: S-EPMC8980128 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature