Evidence of discontinuity between psychosis-risk and non-clinical samples in the neuroanatomical correlates of social function.

ABSTRACT:

Objective

Social dysfunction is a major feature of clinical-high-risk states for psychosis (CHR-P). Prior research has identified a neuroanatomical pattern associated with impaired social function outcome in CHR-P. The aim of the current study was to test whether social dysfunction in CHR-P is neurobiologically distinct or in a continuum with the lower end of the normal distribution of individual differences in social functioning.

Methods

We used a machine learning classifier to test for the presence of a previously validated brain structural pattern associated with impaired social outcome in CHR-P (CHR-outcome-neurosignature) in the neuroimaging profiles of individuals from two non-clinical samples (total n = 1763) and examined its association with social function, psychopa

SUBMITTER: Haas SS 

PROVIDER: S-EPMC8980307 | biostudies-literature | 2022 Sep

REPOSITORIES: biostudies-literature