Desmoplastic Reaction, Immune Cell Response, and Prognosis in Colorectal Cancer.

ABSTRACT:

Background

The relationships between tumor stromal features (such as desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles) and immune cells in the colorectal carcinoma microenvironment have not yet been fully characterized.

Methods

In 908 tumors with available tissue among 4,465 incident colorectal adenocarcinoma cases in two prospective cohort studies, we examined desmoplastic reaction, myxoid stroma, and keloid-like collagen bundles. We conducted multiplex immunofluorescence for T cells [CD3, CD4, CD8, CD45RO (PTPRC), and FOXP3] and for macrophages [CD68, CD86, IRF5, MAF, and MRC1 (CD206)]. We used the inverse probability weighting method and the 4,465 incident cancer cases to adjust for selection bias.

Results

Immature desmoplastic reaction was as

SUBMITTER: Akimoto N 

PROVIDER: S-EPMC8980356 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature