Immunosuppression by piperine as a regulator of the NLRP3 inflammasome through MAPK/NF-κB in monosodium urate-induced rat gouty arthritis.

ABSTRACT:

Background and aim

Gouty arthritis is a metabolic disorder involving monosodium urate (MSU) crystal deposition as a key initiator of acute inflammation. Dysregulation of the nucleotide-binding oligomerization domain, leucine-rich repeat, and pyrin domain-containing protein 3 (NLRP3) inflammasome is associated with the pathogenesis of gout through the maturation of interleukin-1β. Piperine (PIP) is a phytochemical with an anti-inflammatory activity that has the potential as an alternative treatment for gout. In this study, we examined the effect of PIP in immunosuppression of gout inflammation through the regulation of the NLRP3 inflammasome.

Materials and methods

An in silico study was done by pharmacodynamic modeling of PIP in suppressing MSU-induced inflammation thr

SUBMITTER: Jati GAK 

PROVIDER: S-EPMC8980401 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature