EFG1, Everyone's Favorite Gene in Candida albicans: A Comprehensive Literature Review.

ABSTRACT: Candida sp. are among the most common fungal commensals found in the human microbiome. Although Candida can be found residing harmlessly on the surface of the skin and mucosal membranes, these opportunistic fungi have the potential to cause superficial skin, nail, and mucus membrane infections as well as life threatening systemic infections. Severity of infection is dependent on both fungal and host factors including the immune status of the host. Virulence factors associated with Candida sp. pathogenicity include adhesin proteins, degradative enzymes, phenotypic switching, and morphogenesis. A central transcriptional regulator of morphogenesis, the transcription factor Efg1 was first characterized in Candida albicans in 1997. Since then, EFG1 has been re

SUBMITTER: Glazier VE 

PROVIDER: S-EPMC8980467 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature