ABSTRACT: The present dataset contains the chemical parameters of Lake Onego water. The data were obtained in different seasons covering the period 2019-2021. The concentration of Na+ and Cl- ions, the content of organic matter (TOC, CODMn, CODCr, water color, BOD5), nutrients (PO4-P, TP, NH4-N, NO2-N, NO3-N, TN), Fe, Mn, heavy metals (Cu, Ni, Cr, Zn, Cd, Pb), total suspended solids (TSS), conductivity, and pH of water were measured. The analyses were carried out by atomic absorption spectrometry, ICP-MS, spectrophotometric, spectrometric, gravimetric, flamephotometric, titrimetric methods, potentiometric, and conductometric determination. The data are useful for comparative analysis of the hydrochemic