Bleeding After Gastric Endoscopic Submucosal Dissection Focused on Management of Xa Inhibitors.

ABSTRACT:

Purpose

The use of direct oral Xa inhibitors (DXaIs) to prevent venothrombotic events is increasing. However, gastrointestinal bleeding, including that related to endoscopic resection, is a concern. In this study, we evaluated bleeding and coagulation times during the perioperative period of gastric endoscopic submucosal dissection (ESD).

Materials and methods

Patients who consecutively underwent gastric ESD from August 2016 to December 2018 were analyzed. Bleeding rates were compared among the 3 groups (antiplatelet, DXaIs, and control). DXaI administration was discontinued on the day of the procedure. Prothrombin time (PT), activated partial thromboplastin time, and the ratio of inhibited thrombin generation (RITG), which was based on dilute PT, were determined before and

SUBMITTER: Ono S 

PROVIDER: S-EPMC8980599 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature