Injectable hydrogel with nucleus pulposus-matched viscoelastic property prevents intervertebral disc degeneration.

ABSTRACT:

Background/objective

Intervertebral disc (IVD) degeneration (IVDD) that greatly affected by regional biomechanical environment is a major cause of low back pain. Injectable hydrogels have been commonly studied for treatment of IVDD due to their capability of mimicking extracellular matrix structure to support cellular behavior and clinical prospects in minimally invasive treatment. However, most hydrogels suffer from complicated chemistry, potential uncertainty and toxicity from in-situ gelation, and mismatch with IVD mechanical environment that limit their therapeutic effects or clinical translation in IVDD or intervertebral disc defect repair. For IVD lesion repair, the study aims to develop a novel hydrogel with shear-thinning enabled injectability, high bio-safety, and mechanic

SUBMITTER: Jia H 

PROVIDER: S-EPMC8980713 | biostudies-literature | 2022 Mar

REPOSITORIES: biostudies-literature