Divergent Ca²⁺/calmodulin feedback regulation of Ca_V1 and Ca_V2 voltage-gated calcium channels evolved in the common ancestor of Placozoa and Bilateria.

ABSTRACT: Ca_V1 and Ca_V2 voltage-gated calcium channels evolved from an ancestral Ca_V1/2 channel via gene duplication somewhere near the stem animal lineage. The divergence of these channel types led to distinguishing functional properties that are conserved among vertebrates and bilaterian invertebrates and contribute to their unique cellular roles. One key difference pertains to their regulation by calmodulin (CaM), wherein bilaterian Ca_V1 channels are uniquely subject to pronounced, buffer-resistant Ca²⁺/CaM-dependent inactivation, permitting negative feedback regulation of calcium influx in response to local cytoplasmic Ca²⁺ rises. Early diverging, nonbilaterian invertebrates also possess Ca_V1 and Ca_V2 channel

SUBMITTER: Gauberg J 

PROVIDER: S-EPMC8980814 | biostudies-literature | 2022 Apr

REPOSITORIES: biostudies-literature