Dietary salt initiates redox signaling between endothelium and vascular smooth muscle through NADPH oxidase 4.

ABSTRACT: Prevention of phenotype switching of vascular smooth muscle cells is an important determinant of normal vascular physiology. Hydrogen peroxide (H₂O₂) promotes osteogenic differentiation of vascular smooth muscle cells through expression of Runt related transcription factor 2 (Runx2). In this study, an increase in dietary NaCl increased endothelial H₂O₂ generation through NOX4, a NAD(P)H oxidase. The production of H₂O₂ was sufficient to increase Runx2, osteopontin and osteocalcin in adjacent vascular smooth muscle cells from control littermate mice but was inhibited in mice lacking endothelial Nox4. A vascular smooth muscle cell culture model confirmed the direct involvement of the activation of protein kinase B (Akt) with in

SUBMITTER: Ying KE 

PROVIDER: S-EPMC8980891 | biostudies-literature | 2022 Jun

REPOSITORIES: biostudies-literature