Identification of Novel Biomarkers With Diagnostic Value and Immune Infiltration in Burn Injury.

ABSTRACT: Burn injury is an intractable problem in the field of surgery where screening relevant target genes and exploring pathological mechanisms through bioinformatic methods has become a necessity. Herein, we integrated three burn injury mRNA microarray datasets from the Gene Expression Omnibus database to analyze the hub differentially expressed genes (DEGs) between burn injury patient samples and healthy human samples; we conducted multiple functional enrichment analyses and constructed the protein-protein interaction (PPI) network. Finally, we evaluated the immune infiltration in the burn injury microenvironment. A total of 84 intersection DEGs (32 upregulated and 52 downregulated) were screened in burn injury patients via integrated analyses. Upregulated genes were primarily enriched

SUBMITTER: Zhou S 

PROVIDER: S-EPMC8981029 | biostudies-literature | 2022

REPOSITORIES: biostudies-literature