DNA aptamer-based dual-responsive nanoplatform for targeted MRI and combination therapy for cancer.

ABSTRACT: Accurate drug delivery is a common topic, and it has always been an aim that scientists strive to achieve. To address this need, multifunctional and stimulus-sensitive nanoplatforms have attracted significant attention. Here we fabricated a glutathione (GSH) and adenosine-5'-triphosphate (ATP) dual-sensitive nanoplatform for controlled drug release and activatable MRI of tumors based on DNA aptamer and manganese dioxide (MnO₂) nanosheets. Cleverly utilizing the DNA tunability, AS1411 aptamer which binds nucleolin, a protein specifically expressed on tumor-associated endothelial cells, was designed with ATP aptamer and its cDNA to load the anticancer drug, doxorubicin (Dox). The formed DNA-Dox complex was delivered to the tumor region with the help of MnO₂ nanosheets a

SUBMITTER: Zhao M 

PROVIDER: S-EPMC8981167 | biostudies-literature | 2022 Jan

REPOSITORIES: biostudies-literature