The influence of radiation dose on taste impairment in a prospective observational study cohort of oropharyngeal cancer patients.

ABSTRACT:

Background

To analyze the influence of radiation dose on late radiation-associated taste impairment in oropharyngeal cancer (OPC) patients treated with intensity-modulated radiotherapy (IMRT) using the taste bud bearing tongue mucosa as organ at risk.

Material and methods

This study is part of an ongoing, prospective observational study. Cancer-free OPC survivors with at least 24 months from IMRT were included in this analysis. Scores for taste impairment and dry mouth were extracted from the MD Anderson Symptom Inventory Head and Neck module (MDASI-HN) with scores of ≥5 considered as moderate-to-severe symptoms. The mean dose, minimum and maximum dose to the taste bud bearing tongue mucosa, the ipsi- and contralateral parotid and submandibular glands were extracted and anal

SUBMITTER: Stieb S 

PROVIDER: S-EPMC8981169 | biostudies-literature | 2022 Feb

REPOSITORIES: biostudies-literature